2795-41-7, 6-Fluoroindole-3-carboxaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2795-41-7
41 mg of 6-fluoroindole and 42 mg of intermediate I-9 were dissolved in 10 ml of toluene,Add 0.6mg of palladium acetate under N2 protection.And 2.4 mg of Davephos (2-dicyclohexylphosphino-2′-(N,N-dimethylamine)-biphenyl),After stirring and dissolving,Added 32 mg of sodium tert-butoxide.Re-vacuum,Exchange nitrogen,And placed in a 90 C oil bath heated and stirred.After TLC showed that the substrate completely disappeared,The reaction was stopped and the reaction solution was cooled to room temperature.Infiltration is removed by suction filtrationThe filtrate was added with 30 ml of ethyl acetate.40ml water extraction,After the organic layer is washed once,dry,filter,80 mg of compound B-1 (white solid, yield 61.2%) was obtained.
The synthetic route of 2795-41-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Geng Meiyu; Xing Weiqiang; Ding Jian; Ai Jing; (86 pag.)CN103664895; (2018); B;,
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