With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2795-41-7,6-Fluoroindole-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
2795-41-7, A. 6-Fluoro-3-(2-nitropropenyl)-1 H-indole was prepared by combining 6-fluoroindole-3-carboxaldehyde (485 mg, 2.97 mmol), nitroethane (6.0 mL), and ammonium acetate (250 mg, 3.27 mmol). The reaction solution was allowed to reflux 2 hours. The reaction solution was diluted with EtOAc (100 mL), washed with H20 (50 mL x 2), partitioned, dried over Na2SO4, filtered, and concentrated under reduced pressure to provide 560 mg (86 % yield) of 6-fluoro-3-(2-nitropropenyl)-1H- indole ; 1H NMR (CDCI3) b 11.03 (1H, brs), 8.41 (1H, s), 7.63 (1H, dd), 7.50 (1H, s), 7.06 (1H, dd), 6.92 (1H, t), 2.44 (3H, s); TLC (SiO2 plate, 100 % DCM) Rif-0 7
2795-41-7 6-Fluoroindole-3-carboxaldehyde 262903, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; X-CEPTOR THERAPEUTICS, INC.; WO2003/99821; (2003); A1;,
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