Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Organic Letters called Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides, Author is Liao, Jennie; Basch, Corey H.; Hoerrner, Megan E.; Talley, Michael R.; Boscoe, Brian P.; Tucker, Joseph W.; Garnsey, Michelle R.; Watson, Mary P., which mentions a compound: 29046-78-4, SMILESS is COCCOC.Cl[Ni]Cl, Molecular C4H10Cl2NiO2, Safety of Nickel(II) chloride ethylene glycol dimethyl ether complex.
A nickel-catalyzed reductive cross-coupling of alkylpyridinium salts and aryl bromides has been developed using Mn as the reductant. Both primary and secondary alkylpyridinium salts can be used, and high functional group and heterocycle tolerance is observed, including for protic groups. Mechanistic studies indicate the formation of an alkyl radical, and controlling its fate was key to the success of this reaction.
As far as I know, this compound(29046-78-4)Safety of Nickel(II) chloride ethylene glycol dimethyl ether complex can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles