Simple exploration of 310886-79-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.310886-79-4,Methyl 5-fluoro-1H-indole-3-carboxylate,as a common compound, the synthetic route is as follows.

Example 169; 5 -Fluoro- 1 – |Y4-methyl-2-pyridin-2-y l-pyrimidine-5 -carbonyP-amino] – 1 H-indole-3 -carboxylic acid; Step 1 : A solution of 5-fluoro- lH-indole-3-carboxylic acid methyl ester (510 mg, 2.6 mmol) in NMP (6.5 rnL) at rt is treated with KOt-Bu (342 mg, 2.9 mmol) and stirred at rt for 0.5 h. A solution of O-amino-4-nitrobenzoic acid (558 mg, 3.0 mmol) in NMP (2.5 mL) is added and the mixture is stirred for 3 h. The mixture is diluted with EtOAc (50 mL) and washed with 10% aqueous NaHCO3 (50 mL). The organic layer is separated, dried (Na2SO4), filtered and concentrated in vacuo to afford l-amino-5-fluoro-lH-indole-3-carboxylic acid methyl ester, which is used in the next step without further purification., 310886-79-4

As the paragraph descriping shows that 310886-79-4 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS; WO2008/121670; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles