With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32588-36-6,Indole-2-acetic acid,as a common compound, the synthetic route is as follows.
To a solution of compound 7 (100mg, 0.25 mmol)and 2-(1H-indol-2-yl)acetic acid (44 mg, 0.25 mmol) in 5 mlDMF was added HOAT (68 mg, 0.50 mmol), EDCI (78 mg,0.50 mmol) and DIPEA (129 mg, 1 mmol). The mixture wasstirred at 60 C. overnight, LCMS monitored the reaction tocompletion. The target compound 8 (80 mg, 766%) wasobtained as a yellow solid following extraction with EA andfiltration through silica gel.
32588-36-6, As the paragraph descriping shows that 32588-36-6 is playing an increasingly important role.
Reference：
Patent; Acetylon Pharmaceuticals, Inc.; Jones, Simon Stewart; Yang, Min; Tamang, David Lee; US2015/105384; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles