With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-36-7,Ethyl 5-fluoro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
60percent Sodium hydride (197mg, 4.96mmol) was dissolved in 17mL of N, N-dimethylformamide, cooled down to 0¡ãC, ethyl 5-fluoro-1H-indole-2-carboxylate 11b (857mg, 4.14mmol) was added, stirred until there’s no bubbles generated, phenylsulfonyl chloride (0.59mL, 4.59mmol) was added dropwise to be dissolved in 3 mL of N, N-dimethylformamide solution, and the reaction was carried out in an ice bath for 1 hour after the completion of addition. 50mL of water and 100mL of ethyl acetate were added to the reaction solution, the pH was adjusted to neutral with saturated sodium bicarbonate solution. The organic phase was washed with water (50mL*3), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (developing agent: system C) to obtain ethyl 5-fluoro-1-(phenylsulfonyl)-1H-indole-2-carboxylate 11c (1.40g, pale yellow solid), yield: 97.5percent. MS m / z (ESI): 347.9 [M + 1]
As the paragraph descriping shows that 348-36-7 is playing an increasingly important role.
Reference£º
Patent; Zhejiang Hisun Pharmaceutical Co., Ltd; CHEN, Lei; GUAN, Dongliang; BAI, Hua; YAN, Xing; MIAO, Shuai; ZHU, Songsong; (54 pag.)EP3339305; (2018); A1;,
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