With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35320-67-3,2-Methyl-1H-indol-4-ol,as a common compound, the synthetic route is as follows.
Reference example19 2-methyl-1H-indol-4-yloxyphenylmethyl acetic acid benzyl ester Under argon gas, potassium carbonate (2.14g) and bromoacetic acid benzyl (1.08ml) were added to N, N-dimethyl formamide (10ml) solution containing 4-hydroxy-2-methyl-1H-indole (612mg), which was stirred at 60C for 1hour.. water was added to the reactive mixture, which was extracted by ethyl acetate.. The organic layer was sequentially washed with water and saturated brine, and then dried by anhydrous sodium sulfate.. The residue obtained by removal of the solvent was recrystallized by ethylacetate-hexane to give a title compound (1.3g) having the following physical properties. TLC:Rf 0.45 (hexane: ethyl acetate=7:3); NMR(CDCl3):delta 7.87 (brs, 1H), 7.40-7.30 (m, 5H), 7.01-6.94 (m, 2H), 6.44-6.36 (m, 2H), 5.25 (s, 2H), 4.80 (s, 2H), 2.43 (s, 3H)., 35320-67-3
35320-67-3 2-Methyl-1H-indol-4-ol 590225, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1424325; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles