COA of Formula: C8H8O2. In 2019.0 EUR J MED CHEM published article about ALZHEIMERS-DISEASE; A-BETA; TC-99M/RE COMPLEXES; PROBES; PET; RADIOLIGAND; TECHNETIUM; CHALCONE; RE in [Molavipordanjani, Sajjad; Noaparast, Zohreh; Hosseinimehr, Seyed Jalal] Mazandaran Univ Med Sci, Dept Radiopharmacy, Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran; [Molavipordanjani, Sajjad] Mazandaran Univ Med Sci, Student Res Comm, Fac Pharm, Sari, Iran; [Emami, Saeed] Mazandaran Univ Med Sci, Dept Med Chem, Fac Pharm, Sari, Iran; [Emami, Saeed] Mazandaran Univ Med Sci, Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran; [Mardanshahi, Alireza] Mazandaran Univ Med Sci, Dept Radiol, Fac Med, Sari, Iran; [Amiri, Fereshteh Talebpour] Mazandaran Univ Med Sci, Dept Anat, Fac Med, Sari, Iran in 2019.0, Cited 37.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
Six novel 2-arylimidazo[2,1-b]benzothiazole (IBT) derivatives were synthesized as potential tridentate radiotracers for AD imaging purposes. Two of these ligands (6a,b) were successfully labeled with Tc-99m radionuclide at high radiochemical purity using fac-(Tc-99(m)(CO)(3)(H2O)(3)](+) synthon. [Tc-99m]7a and [Tc-99m]7b were evaluated as single photon emission computed tomography (SPECT) imaging agents for A beta plaque in AD. [Tc-99m]7a and (Tc-99m]7b exhibited suitable affinity toward A beta aggregates with IC50 values of 33.2 and 102.5 nM, respectively. The IC50 value of these radiotracers depends on the length of the spacer (alkyl chain). In biodistribution study, these complexes showed good initial brain uptakes (0.78 and 0.86% ID/g at 2 min post-injection) and fast blood clearance. Autoradiography results confirmed that these small Tc-99m complexes (Mw about 600 Da) can bind to A beta plaques in the brain sections of the rat AD model. Histopathological staining with Congo red approved the presence of A beta plaques in these brain sections. (C) 2019 Elsevier Masson SAS. All rights reserved.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Molavipordanjani, S; Emami, S; Mardanshahi, A; Amiri, FT; Noaparast, Z; Hosseinimehr, SJ or concate me.. COA of Formula: C8H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles