With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4792-67-0,Ethyl 5-chloro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
METHOD AD[00234| To a flask was added under argon indole 10 (leq) was added Iodine (1.98 eq.), solid potassium hydroxyde (1 eq.) and anhydrous DMF (4.5mL/mmol). The reaction mixture was stirred 3 hours then water was added and the slurry filtered through paper filter, the solid was dried under reduced pressure and triturated/filtered in water several times to yield after dryed under reduced pressure the 3-iodoindole 61., 4792-67-0
The synthetic route of 4792-67-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IDENIX PHARMACEUTICALS, INC.; WO2008/42240; (2008); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles