With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51417-51-7,7-Bromoindole,as a common compound, the synthetic route is as follows.
196 mg (1 mmol) of 7-bromoindole, 122.4 mg (1.2 mmol) of 5-hydroxy-2-pentanone and 25.6 mg (0.05 mmol) of tris(pentafluorophenyl)boron were added to a 10 mL reaction tube.Stir the reaction at 40 C and monitor by TLC until the sputum disappears.The reaction mixture was extracted with 3¡Á20 mL ethyl acetate.Combine the organic phase,Wash with saturated brine and dry over anhydrous sodium sulfate.Evaporation of the solvent ethyl acetate under reduced pressure and chromatography (ethyl ether: ethyl acetate = 20:1) to give 3-(tetrahydro-2-methyl-2-furanyl)-7-bromo 1H-indole The hydrazine product was 258 mg, yield: 92%.
51417-51-7 7-Bromoindole 2757020, aindole-building-block compound, is more and more widely used in various.
Reference£º
Patent; Huazhong University of Science and Technology; Wang Shijun; Xia Sang; Tang Xiangying; (18 pag.)CN109912579; (2019); A;,
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