52488-36-5, 4-Bromo-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
4-Bromo-lH-indole (1.95g, 10.0 mmol) and KOEta (0.84g, 15.0 mmol) were dissolved in acetone (15 mL). Tosyl chloride (2.86 g, 15 mmol) was added in one portion. The mixture was stirred at room temperature for 2h and concentrated to dryness. The residue was extracted with DCM and water, and washed with brine. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified using silica gel chromatography with (PE:ethyl acetate = 5:1 as mobile phase) to give the title compound as a solid (2.1 g, 60%). LC/MS: m/e = 352 (M+H)+.
The synthetic route of 52488-36-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles