In an article, author is Sun, Minghe, once mentioned the application of 58-85-5, Name is 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, molecular formula is C10H16N2O3S, molecular weight is 244.3106, MDL number is MFCD00005541, category is indole-building-block. Now introduce a scientific discovery about this category, HPLC of Formula: C10H16N2O3S.
Rhodium-Catalyzed Chemodivergent Regio- and Enantioselective Allylic Alkylation of Indoles
The control of C3/N1 chemoselectivity in indole alkylation with the same electrophiles is still challenging. An Rh/bisoxazolinephosphane-catalyzed chemodivergent regioand enantioselective allylic alkylation of indoles was developed. Chiral C3- and N1-allylindoles can be selectively obtained with high branched/linear ratio and up to 99% ee by changing the counteranion of Rh, the allylic carbonate, the reaction temperature, and the ligand.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles