61-54-1, 2-(1H-Indol-3-yl)ethanamine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a refluxing suspension of tryptamine (CAS number 61 -54-1 , available from Combi blocks) (1 .00 g, 6.240 mmol) in 5% trifluoroacetic acid in acetonitrile (100 ml) was added solution of aqueous formaldehyde (37% w/v, 0.50 ml, 6.240 mmol) in acetonitrile (25 ml) drop wise over a period of 30 min and the resulting reaction mixture was allowed to reflux for 24 h. The resulting reaction mixture was cooled to ambient temperature, concentrated under reduced pressure and poured into saturated solution of NaHCC>3 (50 ml) and extracted with ethyl acetate (4 x 25 ml). The combined organic phase was dried over Na2S04, filtered and concentrated under reduced pressure yielding 2,3,4,9-tetrahydro-1H -3-carboline (1.00 g, 5.81 1 mmol) which was used further synthesis without further purification. LCMS: Method B: 3.681 min. MS: ES 173.5 (M+1 ).
As the paragraph descriping shows that 61-54-1 is playing an increasingly important role.
Reference£º
Patent; ARGONAUT THERAPEUTICS LIMITED; MORLEY, Andrew; MILLER, Rebecca; LA THANGUE, Nicholas; (126 pag.)WO2018/167276; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles