With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883500-73-0,5-Bromo-7-fluoro-1H-indole,as a common compound, the synthetic route is as follows.,883500-73-0
A mixture of reagent 1 (30 g, 140.8 mmol), Zn(CN)2 (9.8 g, 84.5 mmol), Zn (2.3 g, 35.2 mmol), Pd2(dba)3 (6.45 g, 7.04 mmol), dppf (7.80 g, 14.1 mmol) in DMA (200 mL) was refluxed for 12 hours under N2. The mixture was cooled to room temperature, filtered and the filtrate was concentrated in vacuo. The residue was extracted with EtOAc (300 mL). The combined organic layers were washed with brine (100 mL), dried over Na2S04 and evaporated to dryness. Flash chromatography (silica, petroleum ether: EtOAc 40:1 to 2:1 ) gave reagent 2 as a yellow solid (15.4 g, 68%). 1H NMR (CDCI3) delta 8.71 (s, 1 H), 7.81 (s, 1 H), 7.38 (m, 1 H), 7.15 (m, 1 H), 6.68-6.70 (m, 1 H).
The synthetic route of 883500-73-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; H. LUNDBECK A/S; ESKILDSEN, J¡ãrgen; WO2014/49133; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles