With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.885519-01-7,6-Bromo-4-chloro-1H-indole,as a common compound, the synthetic route is as follows.
885519-01-7, To a solution of 6-bromo-4-chloro-lH-indole (1 g, 4.34 mmol) in N,N-dimethylformamide (10 ml) and cooled to 0C was added sodium hydride (0.208 g, 5.21 mmol) and the reaction mixture was stirred at 0C during 1 hour. Benzenesulfonyl chloride (0.668 ml, 5.21 mmol) was added and rhe reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with a saturated NH4CI solution and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluting with 5-40% ethyl acetate in cyclohexane) to give 6- bromo-4-chloro-l-(phenylsulfonyl)-lH-indole (1.57 g, 98%) as a beige solid. LC/MS (Method i) Rt = 2.71 min.; no ionisation NMR (DMSO-d6, 300MHz): delta 8.05 (m, 4H), 7.75 (m, 1H), 7.65 (m, 3H), 6.90 (dd, J=3.8, 0.8 Hz, 1H)
The synthetic route of 885519-01-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ABBVIE INC.; ARGIRIADI, Maria A.; BREINLINGER, Eric; CUSACK, Kevin P.; HOBSON, Adrian, D.; POTIN, Dominique; BARTH, Martine; AMAUDRUT, Jerome; POUPARDIN, Olivia; MOUNIER, Laurent; KORT, Michael, E.; (392 pag.)WO2016/198908; (2016); A1;,
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