Recommanded Product: 123-11-5. Authors Reddy, GM; Garcia, JR; Subbaiah, MV; Wen, JC in WILEY published article about in [Reddy, Guda Mallikarjuna] Ural Fed Univ, Chem Engn Inst, Ekaterinburg 620002, Russia; [Garcia, Jarem Raul] Univ Ponta Grossa, Dept Chem, Av Carlos Cavalcanti,4748 Campus Uvaranas,Bloco L, BR-84030900 Ponta Grossa, Parana, Brazil; [Subbaiah, Munagapati Venkata; Wen, Jet-Chau] Natl Yunlin Univ Sci & Technol, Res Ctr Soil & Water Resources & Nat Disaster Pre, 123,Sect 3,Univ Rd, Touliu 640, Yunlin, Taiwan; [Wen, Jet-Chau] Natl Yunlin Univ Sci & Technol, Dept Safety Hlth & Environm Engn, Touliu, Taiwan in 2021, Cited 51. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
Benzothiazole-tethered pyranopyrazoles derivatives were prepared via environmentally favorable conditions, which included eco-friendly catalyst, ethanol-water solvent, one-pot reaction, and atom- and step-economy procedures. Excellent yield of the products was observed. Besides, all products were screened for their antimicrobial behavior. From the biological results, it was seen that most of the compounds possessed high to moderate antimicrobial properties. Compound 6a gave prominent antimicrobial property followed by 6d, 6l, and 6n. In addition, computer-aided studies of the active compounds were also conducted. In this, selected compounds were docked into the intercalation site of DNA of the DNA-gyrase complex. From these results, the highest binding energy of -10.1 kcal/mol was for 6a against DNA-gyrase. This is the first eco-friendly synthetic method for the preparation of benzothiazole-pyranopyrazoles and the synthetic effort in this study may serve as a model for additional environmentally benign reactions. The biological results may prompt further studies related to antibiotic drugs.
Recommanded Product: 123-11-5. Welcome to talk about 123-11-5, If you have any questions, you can contact Reddy, GM; Garcia, JR; Subbaiah, MV; Wen, JC or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles