Smith, Keith published the artcileCarbonylation of various organolithium reagents. A novel approach to heterocycles via intramolecular trapping of aromatic acyllithiums, Related Products of indole-building-block, the main research area is pivaloylaniline pivaloylaminopyridine carbonylation; pivaloyltoluidine carbonylation; cyclization carbonylation pivaloylaniline pivaloylaminopyridine; indole preparation cyclization carbonylation pivaloylaniline pivaloylaminopyridine.
Doubly lithiated N-pivaloylanilines react smoothly with carbon monoxide at 0 °C to give 3-tert-butyl-3-hydroxy-2,3-dihydro-2-indolones in good yields. Similarly, carbonylation of doubly lithiated 4-pivaloylamino- and 2-pivaloylaminopyridines at 0 °C affords the corresponding 5-aza- and 7-aza-3-tert-butyl-3-hydroxy-2,3-dihydro-2-indolones, resp., in good yields. However, carbonylation of doubly lithiated N-pivaloyl-o-toluidines takes a different course due to direct intramol. cyclization of the dilithio reagents to afford 2-tert-butylindoles without uptake of carbon monoxide.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Carbonylation. 69622-40-8 belongs to class indole-building-block, name is 2-(tert-Butyl)-5-chloro-1H-indole, and the molecular formula is C12H14ClN, Related Products of indole-building-block.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles