An article An Efficient Regioselective Synthesis of 8-Formylhomoisoflavonoids with Neuroprotective Activity by Enhancing Autophagy WOS:000644478400047 published article about NATURALLY-OCCURRING HOMOISOFLAVONOIDS; BIOLOGICAL-ACTIVITIES; INHIBITION; CELLS in [Li, Jie; Yang, Fan; Zhang, Fang-Min] Zhejiang Univ City Coll, Sch Med, Dept Pharm, Hangzhou 310015, Peoples R China; [Zeng, Lin-Wei; Zhang, Fang-Min; Zhou, Chang-Xin; Gan, Li-She] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China; [Zhang, Fang-Min; Gan, Li-She] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China in 2021, Cited 24. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Recommanded Product: 4-Methoxybenzaldehyde
6-Formylisoophiopogonone B (7a) and 8-formylophiopogonone B (7b), two natural products isolated from Ophiopogon japonicus, represent a subgroup of rare 6/8-formyl/methyl-homoisoflavonoid skeletons. Herein we report an efficient method for the synthesis of these formyl/methyl-homoisoflavonoids. The synthesized compounds were evaluated for their neuroprotective effects on the MPP(+)induced SH-SYSY cell injury model and showed marked activity. Exploration of the neuroprotective mechanisms of compound 7b led to an increased expression of autophagy marker LC3-II and down-regulation of autophagy substrate p62/SQSTM1. Molecular docking studies showed that 7b may prevent the inhibition of the classic PI3K-AKT-mTOR signaling pathway by interfering with the human HSP90AA1.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles