Recommanded Product: 150-19-6. Recently I am researching about CYCLIC PEPTIDE INHIBITORS; CANCER CELL-GROWTH; DEMETHYLASE 1; POLYAMINE OXIDASE; ANALOGS; TRANYLCYPROMINE; REEXPRESSION; INACTIVATOR; DERIVATIVES, Saw an article supported by the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [1 RO1 CA149095, 1 RO1 CA204345]; Samuel Waxman Cancer Research Foundation; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI) [R01CA204345] Funding Source: NIH RePORTER. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Holshouser, S; Dunworth, M; Murray-Stewart, T; Peterson, YK; Burger, P; Kirkpatrick, J; Chen, HH; Casero, RA; Woster, PM. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol
We have previously described the synthesis and evaluation of 3,5-diamino-1,2,4-triazole analogues as inhibitors of the flavin-dependent histone demethylase LSD1. These compounds are potent inhibitors of LSD1 without activity against monoamine oxidases A and B, and promote the elevation of H3K4me2 levels in tumor cells in vitro. We now report that the cytotoxicity of these analogues in pancreatic tumor cells correlates with the overexpression of LSD1 in each tumor type. In addition, we show that a subset of these 3,5-diamino-1,2,4-triazole analogues inhibit a related flavin-dependent oxidase, the polyamine catabolic enzyme spermine oxidase (SMOX) in vitro.
Recommanded Product: 150-19-6. Welcome to talk about 150-19-6, If you have any questions, you can contact Holshouser, S; Dunworth, M; Murray-Stewart, T; Peterson, YK; Burger, P; Kirkpatrick, J; Chen, HH; Casero, RA; Woster, PM or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles