Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Sun, Ming-Xue, once mentioned the application of 18979-61-8, Name is 4-Butylbenzene-1,3-diol, molecular formula is C10H14O2, molecular weight is 166.22, MDL number is MFCD01684800, category is indole-building-block. Now introduce a scientific discovery about this category, Safety of 4-Butylbenzene-1,3-diol.
Indole alkaloids from Gelsemium elegans
Five previously undescribed monoterpenoid indole alkaloids were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated by HRESIMS, X-ray diffraction, ECD spectra, and molecular modeling. 19,20-Epoxyhumantenine is a humantenine-type alkaloid with an epoxypropyl group at the C-20 position, (4R)-19-oxo-gelsevirine N-4-oxide is a gelsemine-related alkaloid, and gelsedethenine is a gelsedine-type alkaloid with a butenyl group at the C-20 position. Moreover, 10,11-dimethoxy-N-1-demethoxy-gelsemamide is an open-loop indole alkaloid and 11-demethoxy-gelsemazonamide is an aromatic azo-linked dimeric indole alkaloid. Among the five alkaloids, (4R)-19-oxo-gelsevirine N-4-oxide and 10,11-dimethoxy-N-1-demethoxy-gelsemamide exhibited significant inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells, with IC50 values of 6.18 +/- 1.07 and 12.2 +/- 1.02 mu M, respectively.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 18979-61-8, Safety of 4-Butylbenzene-1,3-diol.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles