Synthetic Route of 1953-54-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1953-54-4, Name is 5-Hydroxyindole,introducing its new discovery.
The Friedel-Crafts alkylation (F-CA) reaction is a special kind of carbon?carbon bond formations, which is frequently being used for the formation of such bond in some aromatic rings in organic synthesis. Its asymmetric variant gives enantiorich products. Commonly, an in situ organocatalyzed asymmetric Friedel-Crafts alkylation (AF-CA) proceeds via generation of an enamine as an intermediate. The organocatalyzed-AF-CA was discovered and established in the mid-1980s and reviewed comprehensively in 2010. In this report, we are trying to update the applications of novel organocatalysts in the AF-CA as a versatile synthetic strategy, which is frequently used in the effective asymmetric synthesis of complex molecules, pharmaceutically important compounds and most importantly in the total synthesis of biologically active natural products.
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Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles