Electric Literature of 348640-06-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 348640-06-2, Name is 4-Bromo-7-azaindole, SMILES is BrC1=C2C(=NC=C1)[NH]C=C2, belongs to indole-building-block compound. In a article, author is Liu, Qiang-Qiang, introduce new discover of the category.
Silica gel-promoted synthesis of multisubstituted spiroindolenines from tryptamines and gamma-chloro-alpha,beta-unsaturated ketones
Here we report a one-pot synthesis of multisubstituted spiroindolenines from a series of tryptamine derivatives with gamma-chloro-alpha,beta-unsaturated ketones. The reaction sequence consists of base-induced condensation and silica gel-promoted intramolecular Michael addition. The target molecules are afforded in up to 90% yield with up to >20:1 diastereoselectivity. (C) 2020 Elsevier Ltd. All rights reserved.
Electric Literature of 348640-06-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 348640-06-2.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles