Electric Literature of 487-89-8, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 487-89-8, Name is Indole-3-carboxaldehyde, SMILES is O=CC1=CNC2=C1C=CC=C2, belongs to indole-building-block compound. In a article, author is Wei, Quanpeng, introduce new discover of the category.
Assembly of 7-carboxylate indoles via the Cu-catalyzed coupling of substituted 2-iodobenzoic acids and substituted hydrazines
The CuCl/BFMO catalyzed coupling reaction of substituted 2-iodobenzoic acids and substituted hydrazines took place in the presence of K2CO3 in DMSO at 80 degrees C to afford N-protected N-alkenyl-N’-arylhy-drazines, which were treated with 4 M HCl (or Yb(OTf)(3) and ZnCl2) to afford 7-carboxylate indoles through a [3,3]-sigmatropic rearrangement pathway that is similar to the Fischer indole synthesis. (C) 2019 Elsevier Science. All rights reserved. (C) 2019 Published by Elsevier Ltd.
Electric Literature of 487-89-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 487-89-8.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles