Application of 29342-05-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 29342-05-0, Name is 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, SMILES is O=C1C=C(C)C=C(C2CCCCC2)N1O, belongs to indole-building-block compound. In a article, author is Ali, Rania S., introduce new discover of the category.
Synthesis of Some Novel Fused Pyrimido[4 ”,5 ”:5 ‘,6 ‘]- [1,2,4]triazino[3 ‘,4 ‘:3,4] [1,2,4]triazino[5,6-b]indoles with Expected Anticancer Activity
Our current goal is the synthesis of polyheterocyclic compounds starting from 3-amino[1,2,4]triazino[5,6-b]indole 1 and studying their anticancer activity to determine whether increasing of the size of the molecules increases the anticancer activity or not. 1-Amino[1,2,4]triazino[3′,4′:3,4][1,2,4]triazino[5,6-b]indole-2-carbonitrile (4) was prepared by the diazotization of 3-amino[1,2,4]triazino[5,6-b]indole 1 followed by coupling with malononitrile in basic medium then cyclization under reflux to get 4. Also, new fused pyrimido[4 ”,5 ”:5′,6′-b][1,2,4]triazino-[3′,4′:3,4][1,2,4]triazino[5,6-b]indole derivative 6 was prepared and used to obtain polycyclic heterocyclic systems. Confirmation of the synthesized compounds’ structures was carried out using elemental analyses and spectral data (IR, H-1-NMR and C-13-NMR and mass spectra). The anticancer activity of some of the synthesized compounds was tested against HepG2, HCT-116 and MCF-7 cell lines. The anticancer screening results showed that some derivatives display good activity which was more potent than that of the reference drug used. Molecular docking was used to predict the binding between some of the synthesized compounds and the prostate cancer 2q7k hormone and breast cancer 3hb5 receptors.
Application of 29342-05-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 29342-05-0.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles