Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Melacheu, Gertrude Laura Foudjo, once mentioned the application of 84380-01-8, Name is ¦Á-Arbutin, molecular formula is C12H16O7, molecular weight is 272.2512, MDL number is MFCD09838262, category is indole-building-block. Now introduce a scientific discovery about this category, SDS of cas: 84380-01-8.
Two new indole alkaloid derivatives, 5,6-dioxo-11-methoxy voacangine (1) and (-)-apparicin-21-one (2), together with four known compounds, voacangine (3), ursolic acid (4), 3-methoxyursolic acid (5) and asiatic acid (6) were isolated from the fruits of Tabernaemontana contorta Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR and HRESI-MS measurements. The new indole alkaloids were tested on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells to determine their inhibitory effect on nitric oxide (NO) production, but did not have any significant inhibitory activity. Compound (1) slightly increased the proliferation of RAW 264.7 cells in relation with the increased level of NO released by these cells.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles