In 2019.0 BIOORG CHEM published article about ALPHA-AMYLASE; DERIVATIVES; PIOGLITAZONE in [Bansal, Garima; Monga, Vikramdeep; Thanikachalam, Punniyakoti Veeraveedu; Chawla, Pooja] ISF Coll Pharm, Dept Pharmaceut Chem, Moga 142001, Punjab, India; [Singh, Shamsher] ISF Coll Pharm, Dept Pharmacol, Moga 142001, Punjab, India in 2019.0, Cited 29.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Name: 4′-Hydroxyacetophenone
A series of fourteen novel thiazolidine-2,4-dione derivatives clubbed with pyrazole moiety were synthesized via four step reaction procedure. Reactions were monitored by thin layer chromatography and were characterized by physicochemical and spectrophotometric (IR, Mass, (HNMR)-H-1 and (CNMR)-C-13) analysis. The spectral data were in good agreement with their structures. The title compounds were docked against peroxisome proliferated activated receptors (PPAR-gamma) and alpha-amylase and further evaluated for in vivo and in vitro antidiabetic, in vitro anti-inflammatory and antioxidant activities. Compound GB14 exhibited significant blood glucose lowering activity and was also found to be active inhibitor of alpha-amylase. Compound GB7 was found to be potent anti-inflammatory agent in terms of reducing inflammatory markers (TNF-alpha, IL-beta, MDA) and also showed antioxidant activity to good extent. Therefore, these compounds may be considered as promising candidates for the development of new antidiabetic agents.
Name: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Bansal, G; Singh, S; Monga, V; Thanikachalam, PV; Chawla, P or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles