In an article, author is Bellezza, Delia, once mentioned the application of 111025-46-8, Recommanded Product: 111025-46-8, Name is Pioglitazone, molecular formula is C19H20N2O3S, molecular weight is 356.44, MDL number is MFCD00865504, category is indole-building-block. Now introduce a scientific discovery about this category.
Acceptorless dehydrogenative condensation: synthesis of indoles and quinolines from diols and anilines
The use of diols and anilines as reagents for the preparation of indoles represents a challenge in organic synthesis. By means of acceptorless dehydrogenative condensation, heterocycles, such as indoles, can be obtained. Herein we present an experimental and theoretical study for this purpose employing heterogeneous catalysts Pt/Al2O3 and ZnO in combination with an acid catalyst (p-TSA) and NMP as solvent. Under our optimized conditions, the diol excess has been reduced down to 2 equivalents. This represents a major advance, and allows the use of other diols. 2,3-Butanediol or 1,2-cyclohexanediol has been employed affording 2,3-dimethyl indoles and tetrahydrocarbazoles. In addition, 1,3-propanediol has been employed to prepare quinolines or natural and synthetic julolidines.
If you are interested in 111025-46-8, you can contact me at any time and look forward to more communication. Recommanded Product: 111025-46-8.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles