Recently I am researching about PHOTODYNAMIC THERAPY; ACTIVATABLE PHOTOSENSITIZER; DERIVATIVES; U87, Saw an article supported by the Medical Research Scotland [879-2015]; MSCA Individual Fellowship [704912]; Wellcome Trust Sir Henry Dale Fellowship [100104/Z/12/Z]; Cancer Research UK Early Detection Award [C38363/A26931]; Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission [MR/N013166/1]; National Research Foundation by the Ministry of Science, ICT & Future Planning, South Korea [NRF-2018M3A9H4079286]; ERC Consolidator GrantEuropean Research Council (ERC) [771443]. Product Details of 150-76-5. Published in NATURE RESEARCH in BERLIN ,Authors: Benson, S; de Moliner, F; Fernandez, A; Kuru, E; Asiimwe, NL; Lee, JS; Hamilton, L; Sieger, D; Bravo, IR; Elliot, AM; Feng, Y; Vendrell, M. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol
Metabolites can distinguish pathogenic from healthy cells, but they are hard to couple to current photosensitizers without altering their biological activity. Here the authors design a new family of photosensitizers that retain metabolite function to target pathogenic cells and ablate them by photodynamic therapy. Photoactivatable molecules enable ablation of malignant cells under the control of light, yet current agents can be ineffective at early stages of disease when target cells are similar to healthy surrounding tissues. In this work, we describe a chemical platform based on amino-substituted benzoselenadiazoles to build photoactivatable probes that mimic native metabolites as indicators of disease onset and progression. Through a series of synthetic derivatives, we have identified the key chemical groups in the benzoselenadiazole scaffold responsible for its photodynamic activity, and subsequently designed photosensitive metabolic warheads to target cells associated with various diseases, including bacterial infections and cancer. We demonstrate that versatile benzoselenadiazole metabolites can selectively kill pathogenic cells – but not healthy cells – with high precision after exposure to non-toxic visible light, reducing any potential side effects in vivo. This chemical platform provides powerful tools to exploit cellular metabolic signatures for safer therapeutic and surgical approaches.
Product Details of 150-76-5. About Mequinol, If you have any questions, you can contact Benson, S; de Moliner, F; Fernandez, A; Kuru, E; Asiimwe, NL; Lee, JS; Hamilton, L; Sieger, D; Bravo, IR; Elliot, AM; Feng, Y; Vendrell, M or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles