The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex(SMILESS: COCCOC.Cl[Ni]Cl,cas:29046-78-4) is researched.COA of Formula: C4H10Cl2NiO2. The article 《Synergistic Activation of Amides and Hydrocarbons for Direct C(sp3)-H Acylation Enabled by Metallaphotoredox Catalysis》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:29046-78-4).
The uses of omnipresent, thermodynamically stable amides and aliphatic C(sp3)-H bonds for various functionalizations are ongoing challenges in catalysis. In particular, the direct coupling between the two functional groups was not realized. Here, the authors report the synergistic activation of the two challenging bonds, the amide C-N and unactivated aliphatic C(sp3)-H, via metallaphotoredox catalysis to directly acylate aliphatic C-H bonds using amides as stable and readily accessible acyl surrogates. N-acylsuccinimides served as efficient acyl reagents for the streamlined synthesis of synthetically useful ketones from simple C(sp3)-H substrates. Detailed mechanistic studies using both computational and exptl. mechanistic studies were performed to construct a detailed and complete catalytic cycle. The origin of the superior reactivity of the N-acylsuccinimides over other more reactive acyl sources such as acyl chlorides is an uncommon reaction pathway which commences with C-H activation prior to oxidative addition of the acyl substrate.
In addition to the literature in the link below, there is a lot of literature about this compound(Nickel(II) chloride ethylene glycol dimethyl ether complex)Related Products of 29046-78-4, illustrating the importance and wide applicability of this compound(29046-78-4).
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles