With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10241-97-1,5-Methyl-1H-indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.
In a 50 mL round bottom flask equipped with a magnetic stirrerSelectfluor? (708 mg, 2.0 mmol, 2.0 eq), lithium carbonate (296 mg, 4.0 mmol, 4.0 eq)Then, acetonitrile (3.3 mL) and water (1.7 mL) were added as a solvent and stirred well under an ice bath to maintain the reaction temperature of -20 to 0 ¡ã C,5-methylindole-2-carboxylic acid (175 mg, 1.0 mmol, 1.0 eq) was added slowly; The reaction flask was sealed in an ice bath for 15 hours;After completion of the reaction, the reaction mixture was extracted twice with 20 mL of ether, the organic phases were combined and washed with saturated brine,Dried over anhydrous sodium sulfate; after drying, the organic solvent was dried under reduced pressure in an ice bath to obtain a crude product. The crude product was purified by analytical analysisOf n-pentane as eluant to give the final product: 2-fluoro-5-methyl-1-indoline as a white solid in 52percent yield.
10241-97-1, As the paragraph descriping shows that 10241-97-1 is playing an increasingly important role.
Reference£º
Patent; Central South University; Tang, Zhenyu; Yuan, Xi; Yao, Jianfei; (24 pag.)CN106397377; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles