With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1196-70-9,1H-Indole-6-carbaldehyde,as a common compound, the synthetic route is as follows.
Step 3. Synthesis of (E)-N?-(( 1 H-indol-6-yl)methylene)-2-(4-(furan-3 -yl)-2,6- dimethylphenoxy)acetohydrazide: 2-(4-(furan-3 -yl)-2,6-dirnethylphenoxy)acetohydrazide(40 mg, 0.15 mmol) and 1 H-indol-6-carbaldehyde (22 mg, 0.15 mmol) were dissolved in EtOH2 mL, followed by stirring at 90 C for 3 hours. After the completion of the reaction, thereaction mixture was concentrated under reduced pressure, and purified by columnchromatography (hexane:ethyl acetate = 1:1) to obtain Compound 322 (19 mg, 32 %).?H NMR (400 MHz, DMSO-d6): 6 11.41-11.38 (m, 1H), 11.30-11.20 (m, 1H), 8.50- 8.04 (2s,1H), 8.08 (m, 1H), 7.88 (m, 1H), 7.61 (m, 1H), 7.48-7.37 (m, 2H), 7.38 (m, 1H), 7.27.(m, 3H),6.89 (m, 1H), 6.47 (m, 1H), 4.81 (s, 1H), 4.34 (s, 1H), 2.07 (m, 6H).
The synthetic route of 1196-70-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; CHOI, HoJin; LEE, JaeWon; LEE, ChangGon; HA, NiNa; SEO, Su Kil; LEE, SunMi; LEE, Song-Min; WO2014/35149; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles