With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1196-70-9,1H-Indole-6-carbaldehyde,as a common compound, the synthetic route is as follows.
Example 37. Synthesis of compound 1942-(2-(trifluoromethyl)phenoxy)acetohydrazide (0.2 g, 0.85 mmol) and IH-indol-6-carbaldehyde(0.13 g, 0.85 mmol) were dissolved in ethanol, followed by stirring at 100 C for 16 hours.After the completion of the reaction, the reaction mixture was concentrated under reducedpressure. The concentrate was purified by column chromatography to obtain Compound 194(0.17 g, 55 %).?H NMR (400 MHz, DMSO-d6): oe 11.49-11.26 (m, 2H), 8.27-8.07 (m, 1H), 7.71-7.54 (m, 411), 7.44-7.42 (m, 2H), 7.20-7.06 (m, 2H), 6.45 (s, 1H), 5.3 1-4.80 (m, 2H).
1196-70-9, The synthetic route of 1196-70-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; CHOI, HoJin; LEE, JaeWon; LEE, ChangGon; HA, NiNa; SEO, Su Kil; LEE, SunMi; LEE, Song-Min; WO2014/35149; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles