143612-79-7, 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To the 90cc Acetonitriie added 10 g Methyl-5-(Piperazin -l-yl)-benzofuran- 2- carboxylate , 8.94 g of 3-(4-chlorobuiyl)-l H-indole-5-carbonitrile, 2.64 g Potassium Carbonate, 25.50 g Potassium Iodide and 1.2 g TBAB in catalytic amount. Heated to reflux reaction mass for 24 -30 hrs. Cooled to 25-30C. Added 500 cc aqueous ammonia and 310 cc Acetonitriie and maintained for 72 hrs. Filtered the product at 0-5C after 2 hrs stirring. Washed with water and dried at 60C to obtain 65% 2- benzofurancarboxamide, 5-[4-[4-(5cyano- l H-indol-3-yl)butyl]-l-piperazinyl] Base.
143612-79-7, The synthetic route of 143612-79-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HARMAN FINOCHEM LIMITED; KADAM, Vijay Trimbak; EDAKI, Dhananjay Uddhavrao; ORUGANTI, Nagaraju; MINHAS, Harpreet Singh; MINHAS, Gurpreet Singh; (36 pag.)WO2016/128987; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles