16732-70-0, Ethyl 5-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Ethyl 5-bromoindole carboxylate (1 ‘) (0.10 g, 0.373 mmol) was placed in a round bottom flask,10 mL of acetonitrile was added and 3,5-dimethylthiophenol (0.0516 g, 0.373 mmol, 50 muL) and 1-chloromethyl-4-fluoro-1,4-diazabicyclo [2.2. 2] octane bis (tetrafluoroborate) salt (0.10 g, 0.373 mmol).The reaction was continued for 6 hours.Acetonitrile was evaporated to dryness, 30 mL of water was added, the mixture was extracted with methylene chloride (3 ¡Á 10 mL)The organic phases were combined, washed with saturated brine and dried over anhydrous magnesium sulfate. Filtered and concentrated,Purification by column chromatography (ethyl acetate: petroleum ether = 1: 8).The resulting white solid was recrystallized from ethyl acetate / petroleum ether to give 2 ‘. Yield 50.5%.
16732-70-0 Ethyl 5-bromo-1H-indole-2-carboxylate 259091, aindole-building-block compound, is more and more widely used in various.
Reference£º
Patent; Shandong University; Liu Xinyong; Li Xiao; Zhan Peng; (27 pag.)CN105968095; (2016); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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