With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1912-33-0,Methyl 2-(1H-indol-3-yl)acetate,as a common compound, the synthetic route is as follows.
(2) in a 500 ml round bottom flask methyl indole acetic acid is added in 9.46g (48mmol), ethylene glycol monomethyl ether (40 ml), 5 ml of hydrazine hydrate, 115 ¡ãC heating reflux reaction about 20 hours, thin layer chromatography (TLC) detecting raw material point dematerialised, stop the reaction, cooling to room temperature, adding water (50 ml), static separating white solid, filtering to get the crude product, using ethanol is recrystallized to get indole acetic acid hydrazide white solid 9.2 g.
1912-33-0, As the paragraph descriping shows that 1912-33-0 is playing an increasingly important role.
Reference£º
Patent; Kunming University of Science and Technology; Yunnan University; Xia, Xueshan; He, Yanping; Feng, Yue; Fan, Mengran; Gao, Fengpin; Zhang, Yufang; Li, Cong; (21 pag.)CN105732468; (2016); A;,
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