With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1953-54-4,5-Hydroxyindole,as a common compound, the synthetic route is as follows.
EXAMPLE 10 Preparation of 4-(1H-indol-5-yloxy)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile 130 A mixture of 4-chloro-2-phenylthieno[2,3-b]pyridine-5-carbonitrile 20 (120 mg, 0.44 mmol), 5-hydroxyindole (71 mg, 0.53 mmol) and potassium carbonate (91 mg, 0.66 mmol) in 4 mL of acetonitrile was heated at 80 C. for 5 hours. The reaction mixture was cooled and diluted with 10 mL of water. The precipitate was collected by filtration and washed with water followed by diethyl ether to give 127 mg (79%) of 4-(1H-indol-5-yloxy)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile 130 as an off-white solid, mp 219-221 C., MS 368.1 (M+H)+., 1953-54-4
As the paragraph descriping shows that 1953-54-4 is playing an increasingly important role.
Reference£º
Patent; Boschelli, Diane H.; Cole, Derek C.; Asselin, Magda; Barrios Sosa, Ana C.; Wu, Biqi; Tumey, Lawrence N.; US2007/82880; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles