With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.198479-63-9,5-(Benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole,as a common compound, the synthetic route is as follows.
In a 1000-L reactor, 90 kg of DMSO was added, and 30 kg of 5-(benzyloxy)-2-(4-(benzyloxy) was added at room temperature.Phenyl)-3-methyl-1H-indole was stirred until dissolution, 50 kg sodium hydroxide solids and 12 kg water were added,After activation for 1 h, a solution of compound 4 in DMSO (24 kg of compound 4 dissolved in 210 kg DMF) was added,After reacting for 1 hour at room temperature, the reaction is completed, 600 kg of purified water is added, and the crystals are stirred for 8 hours, filtered, and dried.This gave 42.8 kg of an off-white solid, yield: 91.8%, HPLC purity: 99.5%. .
198479-63-9, As the paragraph descriping shows that 198479-63-9 is playing an increasingly important role.
Reference£º
Patent; Yangzijiang Pharmaceutical Group Co., Ltd.; Wu Jianhua; Xu Jingren; Cai Wei; Zhu Xiaohe; Zhang Haibo; Lv Huimin; Hu Tao; Xiao Can; Gu Cheng; Xu Chenjun; (10 pag.)CN107793344; (2018); A;,
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