24985-85-1, Ethyl 5-hydroxyindole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of ethyl 5-hydroxy-lH-indole-2-carboxylate (250 mg, 1.218 mmol) in N-methyl-2- pyrrolidone (NMP) (2.0 mL) was added benzyl 3,5-dichloro-4-fluorobenzoate (364 mg, 1.218 mmol) followed by DIPEA (1.064 mL, 6.09 mmol) and the mixture was heated in a microwave reactor 200 C 30 min very high then 200 C 6 h very high abs. The crude reaction mixture was partitioned between ether and 1.0 M NaOH, washed with water, dried over magnesium sulfate, and concentrated in vacuo. The evaporation residue was subjected to normal phase purification (0-20 %EtOAc/hexanes) to afford ethyl 5-(4-((benzyloxy)carbonyl)-2,6-dichlorophenoxy)-lH-indole-2- carboxylate (234 mg, 0.483 mmol, 39.7 % yield) as a pale brown solid.1H NMR (400 MHz, CHLOROFORM-i ? ppm 9.28 (br. s., 1 H), 8.13 (s, 2 H), 7.37 – 7.50 (m, 6 H), 7.06 – 7.11 (m, 2 H), 6.91 (d, .7=2.45 Hz, 1 H), 5.41 (s, 2 H), 4.43 (q, .7=7.09 Hz, 2 H), 1.42 (t, .7=7.09 Hz, 3 H). LCMS (2 min TFA): Rt = 1.56 min, [M+H]+= 484.0., 24985-85-1
The synthetic route of 24985-85-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BAILEY, James; CHEN, Yao; HURLE, Mark; LEACH, Craig; TURUNEN, Brandon; (103 pag.)WO2018/134731; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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