With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2795-41-7,6-Fluoroindole-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
Compound 1b (1.0 mmol, 177 mg) was added to a 25 mL sealed tube.Compound 2h (0.5 mmol, 81.6 mg), iodine simple substance (0.5 mmol, 127 mg),Pyridine (0.5 mmol, 39.6 mg) and 1,4-dioxane (2 mL),The reaction was then stirred in an oil bath at 110 C for 12 h. The reaction was quenched by the addition of 50 mL of water and extracted with ethyl acetate (50 mL×3).Washing with 10% Na2S2O3 solution and saturated brine,Dry over anhydrous sodium sulfate. Filter, spin dry,Separated by silica gel column(petroleum ether/ethyl acetate = 10/1, v/v)The product was obtained as a white solid 3s (123.7 mg, 68%)., 2795-41-7
The synthetic route of 2795-41-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Xinxiang Medical University; Gao Qinghe; Liu Xingxia; Yuan Huan; Wang Yakun; Tong Peiyuan; Shen Haotian; Zhang Zhiang; Zhang Weirong; Zhang Jixia; (22 pag.)CN108976198; (2018); A;,
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