2795-41-7, 6-Fluoroindole-3-carboxaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To 15 mL of dichloromethane were added 6-fluoro-1H-indole-3-carbaldehyde (2.32 g, 14.2 mmol) and 4-dimethylaminopyridine (150 mg, 1.23 mmol) in turn. To the mixture was added dropwise di-tert-butyl dicarbonate (4.66 g, 21.3 mmol) at 0 C in a low temperature bath. After the addition, the mixture was reacted at 25 C for 24 hours. To the reaction mixure was added 50 mL of dichlormethane, and the resulting mixture was washed with saturated aqueous sodium bicarbonate (40 mL). The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo and the residue was purified by silica gel chromatography eluted with PE/EA(V/V)= 10/ito give the title compound as a white solid (3.31 g, 88.4%). The compound was characterized by the following spectroscopic data: ?H NMR (600 MHz, CDC13): 6 10.04 (s, 1H), 8.22-8.17 (m, 2H), 7.84 (d, J= 9.6 Hz, 1H), 7.10 (td, J= 9.0, 2.4 Hz, 1H), 1.69 (s, 9H).
2795-41-7, 2795-41-7 6-Fluoroindole-3-carboxaldehyde 262903, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; JIN, Chuanfei; ZHONG, Wenhe; ZHANG, Ji; GAO, Li; CHEN, Kangzhi; WO2015/90233; (2015); A1;,
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