29906-67-0, 1-Methyl-5-nitro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Silver (I) oxide (1 eq.) was added to a stirred solution of indole (1eq.) and benzyl bromide (1 eq.) in dioxane (1 mL/mmol of indole) ina microwave tube under nitrogen gas. The reaction was sealed andstirred at 60 C for 20 h. EtOAc (2 mL/mmol of indole) was added tothe reaction. The reaction was then filtered through celite and thefiltrate was rotovapped. Product was purified by column chromatographyto give a yellow solid; 25-45%; 1H NMR (DMSO): delta 8.42 (d,J 2.3 Hz, 1H), 8.02 (dd, J 9.1, 2.3 Hz, 1H), 7.93e7.84 (m, 2H), 7.60(d, J 9.1 Hz, 1H), 7.44 (d, J 8.3 Hz, 3H), 4.21 (s, 2H), 3.83 (d,J 4.1 Hz, 6H); 13C NMR (DMSO): delta166.59, 147.18, 140.80, 140.05,132.12, 129.82, 129.25, 127.93, 126.82, 116.99, 116.29, 116.03, 110.86,52.45, 33.30, 30.65
29906-67-0, As the paragraph descriping shows that 29906-67-0 is playing an increasingly important role.
Reference£º
Article; Martinez, Anastasia A.; Espinosa, Bianca A.; Adamek, Rebecca N.; Thomas, Brent A.; Chau, Jennifer; Gonzalez, Edwardo; Keppetipola, Niroshika; Salzameda, Nicholas T.; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 1202 – 1213;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles