32387-21-6, 1-Methyl-1H-indole-3-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[0132] Example 9: Synthesis of N-{[3′-bromo-4′-(1H-tetraazol-5-ylmethoxy)-1,1′- BIPHENYL-4-YL] METHYL}-N, L-DIMETHYL-LH-INDOLE-3-CARBOXAMIDE.; [0133] Step 1: 1-METHYL-LH-INDOLE-3-CARBONYL chloride. Oxalyl chloride (7.1 mL, 81.4 mmol) in 50 ML of methylene chloride was added under nitrogen dropwise to a solution of 1-methyl-1H-indole carboxylic acid (2. 86G, 16.3 mmol) in 100 mL of methylene chloride at room temperature. After the addition the reaction was stirred at room temperature until the reaction was determined by NMR analysis to be complete. The solvent and excess oxalyl chloride were removed under reduced pressure. The residue was taken up in benzene and then concentrated to dryness under reduced pressure to give l-methyl-lH-indole-3-carbonyl chloride, which was used in the following reaction without purification.
32387-21-6, As the paragraph descriping shows that 32387-21-6 is playing an increasingly important role.
Reference£º
Patent; WYETH; WO2005/30702; (2005); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles