343-93-1, 1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Synthesis of the Compound of Formula IIIA detailed synthesis of the compound of Formula III from the compound of Formula II is provided below in Scheme III. Step-Wise Procedure:(6-Fluoro-1H-indol-3-ylmethyl)-dimethylamine (65 g), KCN (31 g), DMF (195 ml) and water (104 ml) were charged to the reactor. The reaction mixture was heated to about 100-105 C. (strong reflux) for about 5-8 hours. The reaction mixture was cooled to 20-25 C. Water (780 ml) and toluene (435 ml) were charged to the reactor and the mixture was stirred vigorously for >2 hours. The organic and aqueous layers were separated. The organic layer was washed with 5% NaHCO3 (6×260 ml), 2M HCl (260 ml), 5% NaHCO3 (260 ml) and 5% NaCl (260 ml), respectively. The organic layer was filtered and concentrated to dryness. MeOH (260 ml) was added and the solution was concentrated to dryness. The compound of Formula III was isolated as a brown oil. Yield: 90%. Purity by HPLC (280 nm): 95%. MS m/z: 193 (M+H)+., 343-93-1
As the paragraph descriping shows that 343-93-1 is playing an increasingly important role.
Reference：
Patent; H. LUNDBECK A/S; US2011/152539; (2011); A1;,
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