3468-17-5, (1H-Indol-6-yl)methanamine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 76: Preparation of N-((lH-indol-6-yl)methyl)-5-(4-((2-oxopyridin-l(2H)- yl)methyl)benzyl)nicotinamide A mixture of 5-(4-((2-oxopyridin-l(2H)-yl)methyl)benzyl)nicotinic acid (91 mg, 0.28 mmol, 1.0 eq.), (1H- indol-6-yl)methanamine (44 mg, 0.30 mmol, 1.07 eq.), HATU (114 mg, 0.3 mmol, 1.07 eq.) and DIPEA (0.5 mL) in DCM (3 mL) was stirred at rt overnight. Filtered and the solid was collected and triturated with water to afford N-((lH-indol-6-yl)methyl)-5-(4-((2-oxopyridin-l(2H)-yl)methyl)benzyl)nicotinamide as a white solid (100 mg, 78.7%). LRMS (M+H+) m/z calculated 449.2, found 449.2. NMR (CD3OD, 400 MHz) delta 8.85 (s, 1 H), 8.57 (s, 1 H), 8.09 (s, 1 H), 7.69 (d, 1 H), 7.55-7.51 (m, 2 H), 7.39 (t, 1 H), 7.29-7.22 (m, 5 H), 7.03 (d, 1 H), 6.57 (d, 1 H), 6.43-6.37 (m, 2 H), 5.18 (s, 2 H), 4.67 (s, 2 H), 4.08 (s, 2 H).
3468-17-5, As the paragraph descriping shows that 3468-17-5 is playing an increasingly important role.
Reference£º
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles