3468-18-6, (1H-Indol-4-yl)methanamine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 53 N2-((lH-indol-4-yl)methyl)-N4-(5-(iran^-2-(2-fluorophenyl)cyclopropyl)-lH-pyrazol-3-yl)pyrimidine- 2,4-diamine (1-118)To a solution of 2-chloro-N-(5-(irani’-2-(2-fluorophenyl)cyclopropyl)-lH-pyrazol-3-yl)pyrimidin-4- amine (79, 165 mg, 0.5 mmol) in n-BuOH (5 mL) was added (lH-indol-4-yl)methanamine (110 mg, 0.75 mmol). DIPEA (0.26 mL, 1.5 mmol) was added dropwise then the reaction mixture was placed in a shaker block and heated to 130 C for 20 h. The reaction mixture was cooled and evaporated in vacuo. The crude residue was diluted in DCM (5 mL) and MeOH (5 mL) and then the solvent was evaporated in vacuo. The crude residue was diluted in DMF (2 mL) and filtered. The remaining liquid was removed in vacuo. The residue was purified by reverse phase HPLC to afford 114 mg (52%) of 1-118., 3468-18-6
As the paragraph descriping shows that 3468-18-6 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim; WO2013/26914; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles