With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.399-51-9,6-Fluoro-1H-indole,as a common compound, the synthetic route is as follows.
Place 40 ml DMF in a round bottom flaskSlowly add 6.89 ml of POCl3 (phosphorus oxychloride) under ice bath.After dropping,After stirring in an ice bath for 35 minutes,At a constant pressure dropping funnel was slowly added 5g6- fluoro indole in DMF,Stir at 35 C for 40 min.The reaction solution gradually changed from colorless to red.TLC shows that after the reaction is completed,Add 100ml of 19.3mmol/L aqueous NaOH,Stir vigorously for 30 minutes at 80C.Cool the reaction solutionAdd ethyl acetate extraction,30ml each time,A total of three extractions.Organic layers merge,After drying over anhydrous sodium sulfate,Evaporated to drynessSilica gel column chromatography 4.5g Intermediate I-1 (white solid, yield75%)., 399-51-9
The synthetic route of 399-51-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Geng Meiyu; Xing Weiqiang; Ding Jian; Ai Jing; (86 pag.)CN103664895; (2018); B;,
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