With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.400071-95-6,5-Bromo-1-methyl-1H-indole-3-carboxylic acid,as a common compound, the synthetic route is as follows.,400071-95-6
In a dry flask under argon, the carboxylic acid (2m) (100 mg, 0.39 mmol) was dissolved in dry dichloromethane (3 mL) and few drops of dry DMF. The sluggish solution was cooled to 0 C and freshly distilled oxalyl chloride (60 mg, 0.47 mmol) was added dropwise. The mixture was then stirred for 4 hours at room temperature and directly evaporated with toluene under reduced pressure. The desired acid chloride was obtained as a yellow solid and used straightaway.
The synthetic route of 400071-95-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Universite Joseph Fourier; Denis, Jean-Noel; Jolivalt, Claude, Marcelle; Maurin, Max, Maurin, Louis; Jeanty, Matthieu; EP2548864; (2013); A1;,
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