434958-85-7, N-Boc-5-Hydroxyindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1-(tert-Butoxycarbonyl)-5-hydroxyindole (2.33 g, 10.0 mmol) and triphenylphosphine (5.25 g, 20.0 mmol) were dissolved in toluene (46.0 mL), and the solution was added with glycidol (1.32 mL, 20.0 mmol) and 40% DEAD-toluene solution (9.10 mL, 20 mmol) at room temperature, followed by stirring at 80C for 4 hours. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography (hexane/ethyl acetate=4/1). A crude product (1.28 g) of 1-(tert-butoxycarbonyl)-5-hydroxyindole (1.28 g) was obtained. The obtained crude product was dissolved in N,N-dimethylacetoamide (20.0 mL), and the solution was added with 2- (ethylamino) ethanol (8.60 mL, 87.8 mmol), followed by stirring at 80C for 4 hours. The reaction mixture was added with water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography (chloroform/methanol =9/1) to obtain 1-(tert-butoxycarbonyl)-5-{3-[N-ethyl(2-hydroxyethyl)amino]-2-hy droxypropoxy}indole (1.53 g, 40%). ESI-MS m/z: 379 [M+H]+; 1H-NMR (CDCl3)delta(ppm): 1.07 (t, J = 7.2 Hz, 3H), 1.66 (s, 9H), 2.61-2.80 (m, 6H), 3.61-3.68 (m, 2H), 3.99-4.14 (m, 3H), 6.48 (d, J = 3.9 Hz, 1H), 6.94 (dd, J = 2.6, 8.7 Hz, 1H), 7.04 (d, J = 2.6 Hz, 1H), 7.56 (d, J = 3.9 Hz, 1H), 8.01 (d, J = 8.7 Hz, 1H).
434958-85-7, The synthetic route of 434958-85-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2108642; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles