4769-97-5, 4-Nitroindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: Preparation of methyl (4-chlorophenyl)(4-nitro-lH-indol-l-yl)acetate (1)A solution of 4-nitroindole (6.89 g, 42.5 mmol) in DMF (20 mL) was added dropwise to a stirred suspension of sodium hydride (1.70 g of a 60percent wt/wt dispersion in mineral oil, 42.5 mmol) in DMF (100 mL) at 0 0C. After 10 min, a solution of He (11.2 g, 42.5 mmol) in DMF (20 mL) was added slowly dropwise, and the resulting mixture was stirred at 0 0C for 3 h. The reaction was quenched by addition of saturated aqueous ammonium chloride and extracted with ether. The combined organics were washed with water and brine, dried (MgS04), filtered and concentrated in vacuo. The resulting crude oil was purified by by flashchromatography on silica gel (gradient elution; 0percent-20percent EtOAc/hexanes as eluent) to afford the title compound 1. mlz (ES) 345 (MH)+; IP = C rating.
The synthetic route of 4769-97-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; CRESPO, Alejandro; LAN, Ping; MAL, Rudrajit; OGAWA, Anthony; SHEN, Hong; SINCLAIR, Peter J.; SUN, Zhongxiang; BUNTE, Ellen K. Vande; WU, Zhicai; LIU, Kun; DEVITA, Robert J.; SHEN, Dong-Ming; SHU, Min; TAN, John Qiang; QI, Changhe; WANG, Yuguang; BERESIS, Richard; WO2012/97744; (2012); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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