With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.487-89-8,Indole-3-carboxaldehyde,as a common compound, the synthetic route is as follows.,487-89-8
A mixture of 3-formylindole (16) (11.95 g, 0.0823 mol), crushed sodium hydroxide (9.65 g, 0.241 mol) and tetra-n-butylammonium hydrogen sulfate (1.09 g, 3.21 mmol) in methylene chloride (100 mL) was stirred in an ice bath. Benzenesulfonyl chloride (17.16 g, 0.0972 mol) was added via an additional funnel over 10 min. The resulting mixture was stirred at room temperature for 2 h. Water was added and the organic layer was washed several times with water and dried over magnesium sulfate to afford 17 as a white solid (22.6 g, 96%) after removal of solvent; mp 156-157 C (lit.16 mp 158-158.5 C). 1H NMR (CDCl3) 10.06 (s, 1H), 8.22-8.17 (m, 2H), 7.95-7.89 (m, 3H), 7.58-7.32 (m, 5H).
487-89-8 Indole-3-carboxaldehyde 10256, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Gribble, Gordon W.; Keavy, Daniel J.; Liu, Yanbing; vol. 2019; 6; (2019);,
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